Mechanism of action. Clarithromycin prevents bacteria by acting as a protein synthesis inhibitor. It binds to 23S rRNA, a component of the 50S subunit of the bacterial ribosome, thus inhibiting the translation of peptides. Facebook link: https://www.facebook.com/LeadsCollegeOfPharmacy/ website link: https://pharm.leads.edu.pk/
Views: 308 Leads Group
Developed and produced by http://www.MechanismsinMedicine.com Animation Description: The DNA is shown as a circular double strand within the bacterial cell. Like the DNA of all living organisms, it contains the unique genetic code for all of the proteins required for bacterial survival. These include the proteins required for reproduction, growth, repair and regulation of metabolism. It also codes for the 3 kinds of RNA that are essential for carrying out protein synthesis. These are known as ribosomal RNA (rRNA), messenger RNA (mRNA) and transfer RNA (tRNA). In order for the bacteria to begin protein synthesis, the double-stranded DNA molecule must first unwind and separate in the region which codes for the specific protein that is to be made. Only one strand of the DNA serves as the template for this process known as transcription. Transcription results in the formation of messenger RNA (mRNA) which is a mirror copy of the DNA segment. Once the strand of mRNA is complete, it will detach from the DNA template and in turn become attached to ribosomes. Bacterial ribosomes are made of a small (30S) and a large (50S) subunit. After the 2 subunits join together around the strand of mRNA, synthesis of the polypeptide chain begins. This step involves the aligning of transfer RNA (tRNA) molecules in sequence along the mRNA. Each tRNA carries a unique amino acid (determined by the sequence of the tRNA) which, when aligned along the mRNA and ribosome, join together to form the polypeptide chain. This step is known as translation. The ribosome will continue to add amino acids to the growing polypeptide chain until it reaches a point along the mRNA that signals it to stop. At this point it releases the finished protein molecule. Macrolide antibiotics such as erythromycin, act as inhibitors of protein synthesis by attaching to the 50S ribosomal subunit. By so doing, they block the ability of the ribosome to synthesize the polypeptide chain. By inhibiting protein synthesis, macrolides are considered bacteriostatic antibiotics. However, at higher concentrations and with lower bacterial density or during rapid bacterial growth, macrolides may be bactericidal. Changes or modifications to the 50S ribosomal subunit (i.e. the target binding site for macrolide antibiotics) will confer resistance to macrolides and sometimes other classes of antibiotics. This type of resistance may be of a high level. This mechanism of resistance is mediated by the erm (erythromycin ribosome methlylation) gene which is found on plasmids or transposons (i.e. small genetic elements which are capable of moving from one bacterium to another and integrating into the host chromosomal DNA). Copies of the erm gene are transported to other bacteria via plasmids or transposons through "pili-like" channels. The erm gene is incorporated into the new bacterial genome. During the process of protein synthesis, this bacterium will transcribe and translate the genetic code of the erm gene resulting in the production of a protein enzyme capable of methylating the 50S ribosomal subunit at a specific position. This altered 50S subunit results in decreased binding affinity for macrolides and other antibiotics such as lincosamides (e.g. clindamycin) and streptogramin type B. This pattern of resistance is referred to as the MLS phenotype. Because the macrolide antibiotic is unable to bind to the 50S ribosomal subunit, it is unable to inhibit protein synthesis and thus the bacteria itself is not harmed, continuing to produce polypeptide chains of amino acids. A second mechanism of bacterial resistance to macrolide antibiotics is mediated by efflux pumps. These efflux pumps are encoded by the mef(A) gene which is a transposable element. Because they confer resistance to only macrolides and not lincosamides or streptogramin B they are referred to as the M phenotype. The efflux pumps are energy-dependent and for S. pneuomoniae result in moderate levels of resistance. These pumps traverse the cell membrane of the bacteria and function to "pump out" the macrolide antibiotic after it has entered the bacterium. It should be noted that for other bacteria such as Staphylococcus aureus for example, a different efflux system which is plasmid-mediated and encoded by the msr(A) gene results in macrolide resistance as well as lincosamide and streptogramin resistance in some cases. Despite the presence of these efflux pumps, macrolide antibiotics continue to enter the bacteria. However, once inside the cytoplasm of the bacteria, these efflux pumps actively remove the macrolide antibiotics before they have a chance to reach their target, the 50S ribosomal subunit and bacterial protein synthesis is unaffected.
Views: 216034 Mechanisms in Medicine
Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome. Macrolides mainly affect gram-positive cocci and intracellular pathogens such as mycoplasma, chlamydia, and legionella. Erythromycin was the first macrolide discovered; other macrolides include azithromycin, clarithromycin, and roxithromycin. Their action is primarily bacteriostatic but may be bactericidal at high concentrations, or depending on the type of microorganism.
Views: 10921 Dr.G.Bhanu Prakash - Medical Animations
CBS 2's Dr. Max Gomez has more on who is at risk, and what you should do.
Views: 10484 CBS New York
This antibiotic video tutorial explains the mode of action of 50s ribosome inhibitor antibiotics. These antibiotics are among protein biosynthesis inhibitors. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html
Views: 20776 Shomu's Biology
This antibiotic tutorial explains the mode of action of macrolide antibiotics. It also explains the use and side effects of macrolides in antibacterial treatment. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html
Views: 16047 Shomu's Biology
Grab our free cheatsheet covering the 50 most commonly prescribed medications right here: http://NRSNG.com/50meds Listen to all the episodes at: https://www.nrsng.com/medmaster-podcast/ View the blog post here: https://www.nrsng.com/clindamycin-cleocin/ Clindamycin Generic Name: clindamycin Trade Name: Cleocin Indication skin infections, respiratory tract infections, septicemia, intra-abdominal infections, osteomyelitis Action: bacteriostatic: inhibits protein synthesis Therapeutic Class: Anti-infectives Pharmacologic Class: none Nursing Considerations: arrythmias, pseudomembranous colitis, diarrhea, phlebitis monitor bowel function assess for infection, obtain cultures prior to therapy monitor liver function tests monitor CBC
Views: 11006 NRSNG
Commonly prescribed antibiotic 'clarithromycin ' is linked to an increased risk of cardiac death. Subscribe this channel to watch more motivational, inspirational, valuable and informative videos to soothe, cleanse and inspire your health, mind, body and spirit. Stay tuned and keep watching. Disclaimer:-- Any medical information published on this video is NOT intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Copyright notice:-- "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use."
Views: 2812 Health • Mind • Body • Spirit
Video is created with the help of wikipedia, if you are looking for accurate, professional translation services and efficient localization you can use Universal Translation Services https://www.universal-translation-services.com?ap_id=ViragGNG Video shows what clarithromycin means. A macrolide antibiotic used to treat various conditions.. Clarithromycin Meaning. How to pronounce, definition audio dictionary. How to say clarithromycin. Made with MaryTTS and Wiktionary
Views: 5185 ADictionary
In November 2014 and April 2015, I was severely impacted by two different sets of antibiotics. These antibiotics were Clarithromycin (Biaxin) and Ciprofloxacin (Ciprodex). I have made this video to share my story and to help others adversely affected by antibiotics. In the video I discuss my life prior to the antibiotics, the actual incidents, and my current state of affairs. I share things that have helped me along over the past 3 years and speak about potential better days ahead. Please help me spread the word about the dangers of antibiotics, particularly macrolide antibiotics such as Clarithromycin (Biaxin) and fluoroquinolone antibiotics such as Ciprofloxacin (Ciprodex). Too many unsuspecting people are being severely injured, permanently disabled or worse, killed, by these extremely potent antibiotics. It's time to send a message to pharmaceutical companies, doctors, pharmacists and regulatory agencies such as the Food and Drug Administration (FDA) and Health Canada, that poisoning the masses will no longer be tolerated in our society. ONE INJURY, DISABILITY OR DEATH AS A RESULT OF THESE ANTIBIOTICS IS ONE TOO MANY. PRIMUM NON NOCERE - FIRST DO NO HARM Hippocratic Oath – Medical Ethical Standards To find out more about my story and how I was affected, please visit: https://floxiehope.com/lukaszs-story-clarithromycin-and-ciprofloxacin-poisoning-and-healing/ To find out more about how antibiotics affect other people, please visit: https://floxiehope.com/fluoroquinolone-toxicity-recovery-stories/ Fluoroquinolone A to Z Resource Centre: https://floxiehope.com/ Fluoroquinolone Antibiotics In The News: https://floxiehope.com/fluoroquinolones-links-resources/ The Floxie Hope Podcast: https://floxiehope.com/podcast/ MTHFR Gene Mutation - Full Information: https://wellnessmama.com/27148/mthfr-mutation/ Dr. Josh Axe - Healing Leaky Gut Webinar: https://www.youtube.com/watch?v=6tZHzTWu6Po
Views: 2628 Boy Meets World
Clarithromycin 500 mg tablets these antibiotics ain't worth s*** I'm just the same. As you can see in the f****** video. If you're wondering why it's in two spots because I spit out two loogies in two different spots before showing you https://www.gofundme.com/loveyoutub
Views: 4649 MY LIFE
Paper presented at the Annual Meeting of the Lebanese Pulmonary Society - Mövenpick Hotel - April 24th to 27th, 2013 - Beirut - Lebanon Conférence présentée lors du Congrès annuel de la Société Libanaise de Pneumologie - Hôtel Mövenpick - 24 au 27 avril 2013 - Beyrouth - Liban
Views: 3495 slpsleb
In this video , I have discussed about the Macrolide Antibiotics , their uses and ADVERSE EFFECTS . The Mechanism of Action of Macrolide Antibiotics have been explained as to how they bind to the 50 S subunit of bacterial ribosome and inhibit Protein Synthesis .
Views: 2056 Dr Anshuman Tripathi
Check us out on Facebook for DAILY FREE REVIEW QUESTIONS and updates! (https://www.facebook.com/medschoolmadeeasy) Check out our website for TONS OF FREE REVIEW QUESTIONS! (http://medschoolmadeeasy.com/) Thanks for stopping by, and we love hearing from you! Disclaimer: the information in this video only represents the knowledge and property of the video’s authors- no one else.
Views: 6437 Med School Made Easy
Pharmacology 227.305 2014. Group 25
Views: 396 Rebecca Weal
Grab our free cheatsheet covering the 50 most commonly prescribed medications right here: http://NRSNG.com/50meds Listen to all the episodes at: https://www.nrsng.com/medmaster-podcast/ View the blog post here: https://www.nrsng.com/erythromycin/ Erythromycin Generic Name: erythromycin Trade Name: E-Mycin Indication: useful in place of penicillin when patient cannot take penicillin, upper and lower respiratory tract infections, otitis media, skin infections, pertussis, syphilis, rheumatic fever Action: Bacteriostatic: suppresses bacterial protein synthesis Therapeutic Class: anti-infective Pharmacologic Class: macrolide Nursing Considerations: Causes QT prolongation, ventricular arrhythmias diarrhea asses infection monitor liver function tests instruct patient to finish medication dosage even if they are feeling better medication should not be shared
Views: 11704 NRSNG
5/15 10pm - A potent "go-to" antibiotic that doctors prescribe often could be destroying more than your infection, CALL7 Investigators have discovered.
Views: 13536 Denver7 – The Denver Channel
Tonight a warning about a popular and powerful antibiotic. Tens of thousands of patients across the country including some right here in the bay area report devastating side effects and in some cases death. We went to both the government and to one of the largest drug makers in the country to find out what is being done about it. ◂ The ABC Action News app brings you the latest trusted news and information. ABC Action News is Taking Action For You with leading local news coverage, "Certified Most Accurate" weather forecasts, and award-winning I-Team investigations. ABC Action News, WFTS, covers local news in Tampa Bay and Florida. iPhone: http://bit.ly/http://bit.ly/iOS-wfts Android: http://bit.ly/abcaction-android
Views: 25660 ABC Action News
Антибиотик Кларитромицин ширжоко используется при лечении отитов, синуситов, бронхитов, пневмонии, в лечении гастритов и язвенной болезни.Применение у больных с заболеваниями сердца, даже спустя годы после приема, может приводить к смерти. Healthcare providers should exercise caution when prescribing the macrolide antibiotic clarithromycin (Biaxin, generics) to patients with coronary heart disease because of a potential increased risk for heart problems or death that can occur years later, the US Food and Drug Administration (FDA) said today in a safety communication. The FDA's recommendation is based on 10-year follow-up results of the CLARICOR study, which found an "unexpected" increase in deaths among patients with coronary heart disease who received a 2-week course of clarithromycin that became apparent after patients had been followed for at least 1 year, the agency said.
Views: 752 Dr. Elina Shakh
What are the most common side effects of clarithromycin - Find out more explanation for : 'What are the most common side effects of clarithromycin' only from this channel. Information Source: google
Views: 92 moibrad7b
Claribid 250 Tablets Uses Side effects and Review in Hindi
Views: 2368 Pharmacist Advice
Erythromycin, Azithromycin, Clarithromycin, Telithromycin --- See my website at: http://www.futuredochouse.com/ --- QUPI.com is looking for beta testers! Get limited free access to our Medical Question Bank - http://www.qupi.com/ ---
Views: 950 Future Doc House
Megaklar 125mg ( Clarithromycin ) Antibiotic Syrup Ke Benefits Urdu/ Hindi Megaklar 125mg suspension. ... Medicine Overview of Megaklar 125mg suspension. ... This medicine is used in lower and upper respiratory tract infections, Bronchitis (inflammation in lungs), skin and soft tissue (muscles, tendons, ligaments etc) infections. clarithromycin: What is, what is used for, dose Megaklar Susp 125mg/5ml 60ml-ANTIBIOTICS. CLARITHROMYCIN 125MG/5ML SUSPENSION Patient information for CLARITHROMYCIN 125MG/ 5ML SUSPENSION Including dosage instructions and possible side effects. megaklar uses megaklar 500mg megaklar 250mg clarithromycin 125mg 5ml oral suspension dosage klacid 125mg 5ml dosage klaricid syrup dosage megaklar tablet uses klaricid syrup purpose
Views: 94 Life Care
Free inquiry: https://goo.gl/iVdl1V?54044
Views: 75 Кирилл Кручинкин
My throat is inflamed and sore and I have had conjunctivitis for about a month, so, as it was the weekend, I decided to start taking the clarithromycin again, just for a week to see if I can get these two infections back under control. If it doesn't work, I'll go to the doctor and see what they say.
Views: 2350 ruthheasman
Source: https://www.medindia.net/ For more information, Please visit: https://www.medindia.net/doctors/drug_information/azithromycin.htm Azithromycin belongs to a class of medications called macrolide antibiotics. Azithromycin is used to treat several bacterial infections and works by inhibiting bacterial protein synthesis, thus arresting bacterial growth. Azithromycin is prescribed for treating pneumonia, tonsillitis or pharyngitis, laryngitis, sinusitis, bronchitis, infections of the throat, skin and soft tissue infections, lyme disease, middle ear infections or otitis media, typhoid fever, traveler’s diarrhea and other intestinal infections. Do not take antacids within 2 hours either before or after taking azithromycin as antacids reduce the effectiveness of azithromycin. Please help us translate this video in your language to make it more universal and useful to your language community. We present useful and essential information on the drug azithromycin that everyone should know when taking this drug. Use Medindia drug information to check drug to drug interactions if you are taking more than one drug. Share your comments if you are experiencing any unusual side effects.
Views: 2108 Medindia Videos