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Mechanism of Cisplatin
 
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This project focused more on the visual, not so much on the scientific accuracy. But hope you guys still like it. Check out my website at http://www.molgraphics.com for more of my works. Shown is the cell membrane where cisplatin makes its first contact. There are two ways for cisplatin to enter cell. The first one is simply passively diffuse through the cell membrane. Most cisplatin enters the cell-body through the second pathways, where cisplatin is actively transported by the copper transporter. Once internalized, cisplatin migrates inside the cell and comes into contact with the organelles, such as golgi apparatus, mitochondria, and including the nucleus. Once inside nucleus, cisplatin starts to search for its primary biological target, DNA. Cisplatin losses its two chloride ions and undergoes aquation due to the lower concentration of chloride ion inside cell. It's this more reactive platinum species that actually bind to two consecutive guanine bases within a strand of DNA. Such reaction results in primarily 1,2- or 1,3-intrastrand crosslinks. These adducts can cause the bending of the DNA duplex and facilitate the binding of various proteins such as high-mobility group (HMG) box proteins. Protein-bound DNA adducts induce a number of cellular responses, including cell-cycle arrest, inhibition of DNA replication and transcription process, and cell apoptosis and necrosis.
Views: 25787 Demin Liu
Platinum-Based Chemo Doublets: Backbone for NSCLC Treatment
 
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Dr. Jack West, Swedish Cancer Institute, identifies the platinum-based chemotherapy doublet as the backbone of first-line treatment for the majority of NSCLC patients. http://cancergrace.org/lung/2016/04/15/west_platinum_based_chemo_doublets_backbone_nsclc_treatment/
ASCO 2012: Lung Cancer - Non-small Cell Metastatic Oral Abstract Session
 
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Dr. Sunil Verma, OF Sunnybrook Odette Cancer Center presents highlights from: Lung Cancer - Non-small Cell Metastatic Oral Abstract Session (ASCO 2012): LUX-lung 3, TAILOR, Pemetrexed vs Carboplatin and Pemetrexed in NSCLC PS2, PARAMOUNT.
ASCO 2009: Lung cancer patients lacking MSH2 DNA repair protein fare better with chemo
 
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Pierre Fouret, MD, PhD, Institut Gustave Roussy, Université Pierre et Marie Curie, Paris, France: Speaking at ASCO 2009: Lung Cancer Patients Lacking MSH2 DNA Repair Protein Fare Better with Chemotherapy: An analysis from the International Adjuvant Lung Trial (IALT) reports that tumor levels of the MSH2 protein predict long-term response to cisplatin-based chemotherapy among patients with surgically removed non-small cell lung cancer (NSCLC). MSH2 is a protein that cancer cells use to repair DNA damaged by cisplatin. Researchers found that patients with no or low levels of the MSH2 protein respond better to treatment than patients with high levels.
Views: 265 ecancer
Cisplatin
 
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Cisplatin Cisplatin is a chemotherapy agent It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin1 These platinum complexes react in the body, binding to DNA and causing the DNA strands to crosslink, which ultimately triggers cells to die in a programmed way Cisplatin was discovered in 19722 It is on the World Health Organizations List of Essential Medicines, the most important medications needed in a basic health system3 Contents 1 Medical use 2 Side effects 3 Mechanism of action 31 Cisplatin resistance 32 Transplatin 4 History 5 Synthesis 6 See also 7 References 8 External links Medical use Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid malignancies It is used to treat various types of cancers, including sarcomas, some carcinomas eg, small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer, lymphomas, bladder cancer, cervical cancer,4 and germ cell tumors Cisplatin is particularly effective against testicular can Cisplatin Click for more; https://www.turkaramamotoru.com/en/cisplatin-6050.html There are excerpts from wikipedia on this article and video
Views: 63 Search Engine
Scientists closer to beating cancer
 
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SYDNEY scientists have made a world breakthrough in the treatment of cancer that has potential to save tens of thousands of lives. Working out of a suburban laboratory, they have perfected a therapy to destroy drug-resistant tumour cells. Their new "trojan horse" therapy - which involves the sending of bacterially-derived nanocells into cancer cells in two separate waves - will be published in the July edition of the prestigious Nature Biotechnology medical journal. The Daily Telegraph can reveal that the first human clinical trials involving 20 long-term cancer patients will start within weeks. The treatment, based on nano-sized particles called EDVs, is the result of five years of research and experimentation by Dr Jennifer MacDiarmid and Dr Himanshu Brahmbhatt, at their biotech company EnGeneIC in Lane Cove. "The beauty is that our EDVs (EnGeneIC delivery vehicles) operate like trojan horses ... they arrive at the gates of the affected cells and are always allowed in," Dr MacDiarmid and Dr Brahmbhatt said. "We're playing the rogue cells at their own game. They switch on the gene to produce the protein to resist drugs. We are switching off the gene which, in turn, enables the drugs to enter." Related Coverage * Trojans outsmart tumoursHerald Sun, 29 Jun 2009 * Malcolm in the muddleDaily Telegraph, 29 Jun 2009 * New therapies in fight against cancerNEWS.com.au, 1 Jun 2009 * Success in the lab is a reason for singingThe Australian, 29 May 2009 * Rogue genes key to solve autismCourier Mail, 30 Apr 2009 Conventional drug therapy can kill a large number of cancer cells but a small percentage of those cells produce proteins that make them resistant to chemotherapeutic drugs. "Consequently, follow-up drug treatments can fail," Dr Brahmbhatt said. "The tumours thus become untreatable and continue to flourish, ultimately killing the patient." Chairman of the Australian Cancer Research Foundation's medical research advisory committee Ian Fraser said yesterday the findings were a "significant breakthrough". The benign nature of the EDV technology is expected to enable cancer sufferers to get on with their lives using out-patient therapy. Over the past two years testing has been highly successful in experimental groups by using substantially lower concentrations of drug and antibodies than used in conventional treatments. Similar success has been achieved in early-stage clinical case studies in dogs suffering from relapsed drug-resistant cancers. The reversal of drug resistance, followed by chemotherapy, was extremely effective even in highly aggressive cancers and resulted in 100 per cent survival in mice. Dr Brahmbhatt said: "Our methodology does not damage the normal cells and is applicable to a wide spectrum of solid cancer types. In the future it will help provide what is termed 'tailor-made medicine' geared to individual circumstances."
Views: 3950 jupjupz
Crizotinib, a ready to use drug for NSCLC - ESMO 2012
 
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Luis Paz-Ares describes results of a new drug for ALK-positive NSCLC patients. These studies were presented during ESMO 2012, the Congress of the European Society for Medical Oncology. Read all the news about the latest in cancer and oncology from the Congress here: http://www.esmo.org/Conferences/Past-Conferences/ESMO-2012-Congress/ESMO-2012-News The opinion expressed in this interview reflects that of the interviewee and does not necessarily express the official ESMO point of view. Video produced by the European Society for Medical Oncology (ESMO)
Cisplatin | RMIT University
 
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The role of platinum in cancer treatment.
Views: 166 RMIT University
KEYNOTE-189: Key Summary of a Practice-Changing Trial in Advanced Non-Squamous NSCLC (BMIC-030)
 
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Dr. Jack West reviews the trial design, efficacy endpoints, and toxicity results of the KEYNOTE-189 trial of pembrolizumab or placebo added to cisplatin or carboplatin with pemetrexed chemo in advanced non-squamous NSCLC with any PD-L1 expression. Visit http://BeaconMedIC.com for more media & information.
Views: 350 BeaconMedIC
Iressa, cancer information - english
 
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Iressa, informationsfilm om cancer för Suddholm Iressa, information video about cancer for Suddholm Voiceover: Swedish female top VO Nina Nu
Views: 1851 Nina Nu Media AB
What is Acquired Resistance and How Does it Occur?
 
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http://cancerGRACE.org/ Acquired Resistance Forum Video #1: Dr. Gregory J. Riely of Memoral Sloan Kettering Cancer Center opened the Acquired Resistance in Lung Cancer Patient Forum with a basic introduction of how ALK, ROS1 and EGFR lung cancers become resistant to treatment. September 2014 GRACEcast 274 Lung
Understanding your treatment: Cisplatin or Carboplatin with Etoposide
 
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This video will review the schedule and treatment with Cisplatin or Carboplatin with Etoposide. You should first watch the general chemotherapy video on this site prior to viewing this video.
Views: 113562 charlottecancer
How anticancer drugs work - Molecular mechanism of action of cisplatin
 
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Cisplatin is an anticancer drug; Mechanism includes crosslinking of DNA, which triggers apoptosis. It is used to treat many types of cancers including testicular, lung, cervical, bladder, head and neck, and ovarian cancer. Cisplatin requires intensive intravenous hydration and treatment may be complicated by severe nausea and vomiting. Cisplatin is toxic, causing nephrotoxicity (monitoring of renal function is essential), ototoxicity, peripheral neuropathy, hypomagnesaemia and myelosuppression. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
Views: 7018 learningisfun
Jeffrey Settleman, Ph.D., The Many Flavors of Resistance To Anti-Cancer Drugs
 
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Jeffrey Settleman, Ph.D., the Senior Director of Discovery Oncology at Genentech, discussed his work investigating non-genetic/nonmutational drug-resistance to cancer therapeutics. "Understanding Signaling Pathways in Cancer", a symposium presented by the Koch Institute in partnership with Cell Signaling Technology, brought together speakers from leading cancer research organizations to present their latest findings on the signaling pathways leading to cancer.
Chemotherapy Resistance: The Fault in Our Cells
 
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Cells in tumors mutate very quickly as they grow and divide, creating a tumor with multiple populations of different cells. In this 45-minute lesson students will learn how these mutations can result in tumor heterogeneity and make tumors more sensitive or resistant to chemotherapy treatment. Students participating should have a basic understanding of cellular division (mitosis) and DNA structure and replication. Using this knowledge, students will run a tumor growth and treatment simulation to model how a tumor’s heterogeneous composition can change the efficacy of chemotherapy treatment. We’ve included an optional statistics segment where students can apply basic statistical techniques to analyze data generated in the experiment; students participating in this optional activity should have an understanding of basic statistics. In order to complete this lesson, you’ll need paper bags, beads/beans/similar materials of five different colors, cups, and one timer. For each group of three students, you will need 1 paper bag, 6 cups (or other bead-holding vessels), and 25 beads of each color. For more information: http://blossoms.mit.edu/videos/lessons/chemotherapy_resistance_fault_our_cells
Views: 160 MIT BLOSSOMS
What is TUMOR METABOLOME? What does TUMOR METABOLOME mean? TUMOR METABOLOME meaning
 
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What is TUMOR METABOLOME? What does TUMOR METABOLOME mean? TUMOR METABOLOME meaning - TUMOR METABOLOME definition - TUMOR METABOLOME explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in tumor cells. The characteristic attributes of the tumor metabolome are high glycolytic enzyme activities, the expression of the pyruvate kinase isoenzyme type M2, increased channeling of glucose carbons into synthetic processes, such as nucleic acid, amino acid and phospholipid synthesis, a high rate of pyrimidine and purine de novo synthesis, a low ratio of Adenosine triphosphate and Guanosine triphosphate to Cytidine triphosphate and Uridine triphosphate, low Adenosine monophosphate levels, high glutaminolytic capacities, release of immunosuppressive substances and dependency on methionine. Although, the link between the cancer and metabolism was observed in early days of cancer research by Otto Heinrich Warburg, which is also known as Warburg hypothesis, but not much of the substantial research was done until the late 1990s because of the lack of in vitro tumor models and creating environments that lack oxygen. Recent research has revealed that metabolic reprogramming occurs as a consequence of mutations in cancer genes and alterations in cellular signaling. Therefore, the alteration of cellular and energy metabolism has been suggested as one of The Hallmarks of Cancer. High amount of aerobic glycolysis (also known as the Warburg effect) distinguishes cancer cells from normal cells. The conversion of glucose to lactate rather than metabolizing it in the mitochondria through oxidative phosphorylation, (which can also occur in hypoxic normal cells) persists in malignant tumor despite the presence of oxygen. This process normally inhibits glycolysis which is also known as Pasteur effect. One of the reasons it is observed is because of the malfunction of mitochondria. Although ATP production by glycolysis can be more rapid than by oxidative phosphorylation, it is far less efficient in terms of ATP generated per unit of glucose consumed. Rather than oxidizing glucose for ATP production, glucose in cancer cells tends to be used for anabolic processes, such as ribose production, protein glycosylation and serine synthesis. This shift therefore demands that tumor cells implement an abnormally high rate of glucose uptake to meet their increased needs. As neoplastic cells accumulate in three-dimensional multicellular masses, local low nutrient and oxygen levels trigger the growth of new blood vessels into the neoplasm. The imperfect neovasculature in the tumor bed is poorly formed and is inefficient. It therefore, causes nutrient and hypoxic stress (or a state of hypoxia). In this regard, cancer cells and stromal cells can symbiotically recycle and maximize the use of nutrients. Hypoxic adaptation by cancer cells is essential for survival and progression of a tumor. In addition to cell-autonomous changes that drive a cancer cell to proliferate and contribute to tumorigenesis, it has also been observed that alterations in whole-organism metabolism such as obesity are associated with heightened risks for a variety of cancers. It has also been seen that metabolic phenotype of tumor cells changes to adapt to the prevailing local conditions. Some of the fatty acids have been linked to acquire resistance against some of the cancer drugs. Fatty acid synthase (FASN), a key complex catalyzing fatty acid synthesis has been found to be linked to acquired docetaxel, trastuzumab and adriamycin resistance in breast cancer. Similar resistance have been found with intrinsic gemcitabine and radiation resistance in pancreatic cancer. Glutaminolysis is linked to cisplatin resistance via the activation of mTORC1 signaling in gastric cancer. NADPH plays an important role as an antioxidant by decreasing the reactive oxygen produced during rapid cell proliferation. It has been shown that attenuation of the PPP would dampen NADPH production in cancer cells, leading to the decrease in macromolecular biosynthesis and rendering the transformed cells that are vulnerable free radical-mediated damage. In this way, the advantage conferred by PKM2 expression would be eliminated. In preclinical studies, drugs such as 6-amino-nicotinamide (6-AN), which inhibits G6P dehydrogenase, the enzyme that initiates the PPP have shown anti-tumorigenic effects in leukemia, glioblastoma and lung cancer cell lines.
Views: 154 The Audiopedia
Symposium 2014: Tumor Heterogeneity in Cancer Drug Response, Resistance, and Relapse
 
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Dr. Erica Jackson of Genentech describes enrichment of cells with stem cell markers in populations of lung cancer cells. For more information on the NCI National RAS Initiative, visit http://www.cancer.gov/RAS?cid=VIDEOras.
USMLE Hematology and Oncology 21 Oncology and Pharmacology
 
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Welcome to LY Med, where I go over everything you need to know for the USMLE STEP 1, with new videos every day. Follow along with First Aid, or with my notes which can be found here: https://www.dropbox.com/sh/t5tfdbhucbanuj9/AADX0mIFMcROsHytv8_nLwIPa?dl=0 Shout out to the reddit user littlebrosencephalon for some of his notes and diagrams used here. Our last video for our heme and onc block! This video is all on cancer pharmacology, discussing how they work and their side effects. We start by drawing our cell cycle, seeing where we can manipulate it to stop cancerous cells from proliferating. Our first drug class is the anti-metabolites, which are drugs that interfere with DNA synthesis. These include drugs such as : 6-MP, cladribine, 6-thioguanin, cytarabine, 5FU, methotrexate and hydroxyurea. Our next class of drugs include topoisomerase inhibitors, which block the unwinding of DNA during replication. These include: topotecans, and etoposide. Moving on to anti-cancer antibiotics. These stop bacterial and DNA synthesis and include bleomycin, actinomycin D, and doxorubicin. Almost done! Next up is microtubule inhibitors, that blocks the formation and division of cells during M phase. These drugs include vinca alkaloids and paclitaxels. The last drug class is alkylating agents, which bind and crosslink DNA. These drugs are non cell cycle specific and include busulfan, cyclophosphamide, nitrosoureas, and platinum agents like cisplatin. That's it folks! All done with heme and onc!
Views: 1387 LY Med
HYDROGEN SKIN CARE Nu UH2 Molecular Hydroceutical
 
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The ULTRA H2 MOLECULAR HYDROGEN The Ultra H2 Molecular hydrogen creates up to 1,500 part per billion molecular hydrogen which readily turns your potable water into a SUPER ANTI-OXIDANT water! How can Molecular Hydrogen Water Benefit You and Your Family?? Hydrogen water contains hydrogen molecules that act as powerful antioxidants. These molecules help neutralize oxygen free radicals that causes diseases, inflammation and aging. Because of its unique properties, molecular hydrogen has therapeutic benefits in virtually every organ in the body where it exerts antioxidant, anti-inflammatory, anti-obesity, and anti-allergy actions with no known side effects. Hydrogen Water Benefits -an antioxidant and prevents brain damage -can protect cells and tissues from oxidative damage -prevents the development of Parkinson's disease -reduces neurotoxic damage -improve mood disorders -may be used for improving depression and some mental disorders -suppresses inflammation -reduces muscle fatigue, motor deficits and muscle degeneration -reduces lactic-acid buildup during heavy exercise -can improve muscular dystrophy -prevents metabolic syndrome -reduces fatty liver wth type 2 diabetes and obesity -prevents atherosclerosis -increases good cholesterol -help in weight loss -controls body fat and weight -directly protects the mitochondria -stimulates energy metabolism -treats diabetes -decreases bad cholesterol -normalizes glucose tolerance -improves insulin resistance -may treat metabolic acidosis -increases the pH of the blood -prevents cancer -an anti-tumor agent -suppresses tumor colony growth -inhibits blood vessel growth in human lung cancer cells -reduces side effects of cancer treatments -improves mortality and body weight loss caused by an anti-cancer drug, cisplatin -reduces kidney toxicity -prevents the loss of appetite on patients receiving radiation therapy -boosts skin health -improves wrinkles in the skin -reduces human skin cell damage from ultraviolet rays -enhances wound healing -limits damage of transplant organs -improves bladder dysfunctions -is cardio-protective -improves heart muscle function -protects the eye -if used as eyedrops, facilitates the recovery process after retinal injury -may prevent blindness caused by chemical burns of the eye -prevents hearing loss -protects auditory hair cells from oxidative damage -combats allergy -improves symptoms of atopic dermatitis -ameliorates kidney disease -reduces inflammation and blood pressure in hemodialysis patients -protects the liver -promotes gut health -protects the lungs -protects against radiation -relieves pain -prolongs life span -is antibacterial -promotes oral health So how can you convert your potable drinking water into Molecular Hydrogen Water? AIM Global introduces its newest product, ULTRA H2, an advanced Japanese Technology made in South Korea! It creates up to 1,500 parts per billion (PPB) of Molecular Hydrogen, the highest molecular hydrogen Generator! Just put Potable water inside and it will turn it into super-antioxidant water! And it costs much much lower than the machines being sold in the market today! When it comes to yours and your family's well-being, you should not aettle for anything less than the best, safest and most beneficial product! ULTRA H2 is going to change your life! It will become your most trustworthy ally in your efforts to stay beautiful and healthy!
Views: 122 Reshyl Ann Laurito
Tumor Cells More Effectively Killed With New Platinum Drug
 
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A new experimental drug based on platinum, called phenanthriplatin, is being tested by researchers at Massachusettes Institute of Technology. The researchers claim this drug kills cancer cells more effectively than cisplatin, the most commonly approved platinum chemotherapy drug.
Views: 85 EmpoweredDoctor
2015 World Conference on Lung Cancer
 
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Laura Jones reports on findings from the 2015 World Conference on Lung Cancer, including results for the combination of nivolumab and ipilimumab, atezolizumab and chemotherapy, osimertinib in resistant lung cancer, and more.
Views: 185 OncLiveTV
Video Squamous Lung Cancer Treatment
 
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http://cancerGRACE.org/ Dr. David Spigel, Sarah Cannon Cancer Center, outlines treatment options for squamous lung cancer. GRACEcast 180 Lung
Edward Kim, MD, comments on gefitinib versus vinorelbine-cisplatin as adjuvant treatment in NSCLC
 
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Dr. Kim, Medical Oncologists, Levine Cancer Institute, compares gefitinib versus vinorelbine-cisplatin ad adjuvant treatment in stage II-IIIA (N1 N2) NSCLC with EGFR-activating mutation
Views: 81 OBRoncology
Platinum compound improves cancer treatment
 
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Researchers at Warwick University are developing a platinum compound which could improve the treatment of cancer.
Views: 1171 WarwickICAST
[3D] Mechanism of Iressa Drug Resistance
 
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Note on 3D video: 3D videos on youtube are best viewed with a 3D viewing system such as a 3D TV or a stereoscopic 3D capable computer. There is an option for colored glasses, but youtube does the conversion so unless your glasses match youtube's specifications, they won't work as well. If you don't have a viewing system you can try the no glasses option: you can view the video in 3D by crossing your eyes to merge the left and right view, similar to how stereograms work. However this can be difficult to pull off and could give you a headache. Protein kinases are a group of enzymes that transfer a phosphate from a molecule, such as the cofactor ATP, to one or more amino acid residues in a signaling protein. Over-functioning results in uncontrollable growth of cells, a tumor formation. ATP binds in the ATP-binding site of the tyrosine kinase domain and makes 2 important hydrogen bonds to the protein. A threonine side-chain at position 790 is present in the binding interaction. The binding of ATP to the tyrosine kinase domain of the protein leads to phosphorylation of the tyrosine residue, and as a result, proliferation of cells. The drug Iressa or Gefitinib is a Tyrosine Kinase inhibitor that blocks the binding of ATP, and thus no phosphorylation. Although it is similar in size, Iressa does not resemble the structure of the ATP molecule, but the drug binds in the ATP-binding pocket and prevents the protein from phosphorylation.
Views: 2473 URIanimation
Monotherapy Administration of Sorafenib in Patients with Non-Small Cell Lung Cancer
 
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Vienna, ESMO 2012, Pressconference September 29: Dr Luis Paz-Ares, Oncology Service, Hospital Virgen del Roc, Seville/SPAIN Monotherapy Administration of Sorafenib in Patients with Non-Small Cell Lung Cancer: Phase III, Randomized, Double-Blind, Placebo-Controlled MISSION Trial.
Views: 159 oncoletter
Researchers show aspirin added to cancer drug improves effectiveness
 
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Adding aspirin to some existing cancer drugs could increase their effectiveness against a group of tumours resistant to treatment, new research has shown. University of Queensland scientists are hoping clinical trials could soon be underway for people with lung, pancreatic and colorectal cancers that have not responded to other therapies.
Overview of Iressa a Prescription Medication Used to Treat Non-Small Cell Lung Cancer
 
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http://www.rxwiki.com/iressa Iressa is a prescription medication used to treat non-small cell lung cancer. Iressa belongs to a group of drugs called protein kinase inhibitors. It is thought to work by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells grow and multiply. This medication comes in tablet form and is taken once a day, with or without food. Common side effects include diarrhea, rash, acne, dry skin, and nausea.
Views: 634 RxWikiTV
Chemoresistance
 
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Views: 200 Josh Andersen
Cytotoxicity of cisplatin on 3D spheroid tumor cells – Video abstract [ID 108004]
 
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Video abstract of an original research paper “Real-time monitoring of cisplatin cytotoxicity on three-dimensional spheroid tumor cells” published in the open access journal Drug Design, Development and Therapy by Baek et al. Three-dimensional (3D) cell cultivation is a powerful technique for monitoring and understanding diverse cellular mechanisms in developmental cancer and neuronal biology, tissue engineering, and drug development. 3D systems could relate better to in vivo models than two-dimensional (2D) cultures. Several factors, such as cell type, survival rate, proliferation rate, and gene and protein expression patterns, determine whether a particular cell line can be adapted to a 3D system. The 3D system may overcome some of the limitations of 2D cultures in terms of cell–cell communication and cell networks, which are essential for understanding differentiation, structural organization, shape, and extended connections with other cells or organs. Here, the effect of the anticancer drug cisplatin, also known as cis-diamminedichloroplatinum (II) or CDDP, on adenosine triphosphate (ATP) generation was investigated using 3D spheroid-forming cells and real-time monitoring for 7 days. First, 12 cell lines were screened for their ability to form 3D spheroids: prostate (DU145), testis (F9), embryonic fibroblast (NIH-3T3), muscle (C2C12), embryonic kidney (293T), neuroblastoma (SH-SY5Y), adenocarcinomic alveolar basal epithelial cell (A549), cervical cancer (HeLa), HeLa contaminant (HEp2), pituitary epithelial-like cell (GH3), embryonic cell (PA317), and osteosarcoma (U-2OS) cells. Of these, eight cell lines were selected: NIH-3T3, C2C12, 293T, SH-SY5Y, A549, HeLa, PA317, and U-2OS; and five underwent real-time monitoring of CDDP cytotoxicity: HeLa, A549, 293T, SH-SY5Y, and U-2OS. ATP generation was blocked 1 day after addition of 50 μM CDDP, but cytotoxicity in HeLa, A549, SH-SY5Y, and U-2OS cells could be visualized only 4 days after treatment. In 293T cells, CDDP failed to kill entirely the culture and ATP generation was only partially blocked after 1 day. This suggests potential CDDP resistance of 293T cells or metabolic clearance of the drug. Real-time monitoring and ATP measurements directly confirmed the cytotoxicity of CDDP, indicating that CDDP may interfere with mitochondrial activity. Read this original research paper here: https://www.dovepress.com/real-time-monitoring-of-cisplatin-cytotoxicity-on-three-dimensional-sp-peer-reviewed-article-DDDT
Views: 593 Dove Medical Press
What Is Carboplatin Used To Treat?
 
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Carboplatin (paraplatin) side effects & cancer treatment carboplatin (intravenous route) description and brand names chemotherapy for non small cell lung. Googleusercontent search. It is a chemotherapy drug that contains platinum. It may also be used to treat other kinds of 16 2016 chemotherapy (chemo) is a treatment cancer killing drugs kill if combination used, it often includes cisplatin or carboplatin plus 14 jun 2017 chemo at different times during for esophageal and paclitaxel (taxol ) (which combined with 4 feb iv chemotherapy, most doctors favor over the drug combinations germ cell tumors are 23 which bladder cancer? Carboplatin either docetaxel (for patients poor kidney function) find out who might offered carboplatin, how works, given associated potential side effects. Chemotherapy for bladder cancer american societyparaplatin (carboplatin) patient information side effects and drug carboplatin use against mesothelioma &. Carboplatin platinum based chemotherapy agent. Carboplatin is a treatment for many different types of 15 dec 2012 carboplatin used alone or in combination with other medications to treat cancer the ovaries (cancer that begins female reproductive 1 sep 2016 uses advanced stage breast and usually given chemotherapy medicines carboplatin, sold under trade name paraplatin among others, medication number forms. Carboplatin may be used to treat people with pictures of paraplatin (carboplatin), drug imprint information, side effects for the carboplatin is together other cancer medications ovarian carboplatin, one main chemotherapy drugs in mesothelioma treatment, kills rapidly dividing cells and extend life expectancy. After treatment with carboplatin has ended, normal hair growth should return. Carboplatin cancer information macmillan support carboplatin drug chemocare chemotherapy. During treatment, you will usually see a cancer doctor, chemotherapy nurse or specialist. Find out what carboplatin is, how you have it and other important information about having. Carboplatin cancer information macmillan supportcarboplatin intravenous uses, side effects, interactions, pictures carboplatin support. Chemotherapy for ovarian cancer american society. Aspx url? Q webcache. Carboplatin injection medlineplus drug informationcarboplatin taxol national cancer institute. Carboplatin side effects in detail drugs cancer research uk. They might cause other unwanted effects that may not occur until months or years after the medicine is used. Carboplatin is used to treat ovarian cancer. This includes ovarian 30 may 2012 carboplatin taxol is used to treat this combination also be with other drugs or treatments types of cancer for treatment. It is used to treat cancer of the ovaries. It is used alone or in combination with other medications to slow stop cancer cell growth carboplatin a chemotherapy drug treat ovarian and lung. Your nurse will usually give you anti sickness drugs as an injection into a vein before the chemotherapy learn about
Views: 224 Question Bank
FWLAB UAlberta '14: Breaking the Wall of Cancer Therapy Resistance
 
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At UAlberta's first Falling Walls Lab, MD/PhD student Matthew Benesch shared his idea to improve cancer therapy and patient outcomes by blocking inflammatory signals and survival pathways. Matthew believes understanding autotaxin holds potential diagnostic and therapeutic benefits and his research has shown some real success. He is now working with pharmaceutical industry partner to test his idea and headed to clinical trials.
Views: 962 UniversityofAlberta
Dr. Scagliotti Discusses Elderly Lung Cancer Therapy
 
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Giorgio V. Scagliotti, MD, PhD, head of the Thoracic Oncology Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Italy, discusses the challenges facing lung cancer treatment in elderly populations. Scagliotti explains that elderly patients now represent approximately 30% of new non-small cell lung cancer (NSCLC) patients. Despite this fact there hasn't been any major recent advances in the treatment of elderly patients with NSCLC. The current standard treatment for NSCLC is chemotherapy that is either a targeted therapy or a classic cytotoxic agent. Administering combination therapies becomes difficult for elderly patients because only a minority is fit enough for this type of treatment. The degree of comorbid conditions is increased in elderly patients due to their physiological state. These conditions are exceptionally common when giving cisplatin, which is the backbone of many combinations therapies.
Views: 170 OncLiveTV
ULTRA H2 Unboxing
 
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The ULTRA H2 MOLECULAR HYDROGEN The Ultra H2 Molecular hydrogen creates up to 1,500 part per billion molecular hydrogen which readily turns your potable water into a SUPER ANTI-OXIDANT water! How can Molecular Hydrogen Water Benefit You and Your Family?? Hydrogen water contains hydrogen molecules that act as powerful antioxidants. These molecules help neutralize oxygen free radicals that causes diseases, inflammation and aging. Because of its unique properties, molecular hydrogen has therapeutic benefits in virtually every organ in the body where it exerts antioxidant, anti-inflammatory, anti-obesity, and anti-allergy actions with no known side effects. Hydrogen Water Benefits -an antioxidant and prevents brain damage -can protect cells and tissues from oxidative damage -prevents the development of Parkinson's disease -reduces neurotoxic damage -improve mood disorders -may be used for improving depression and some mental disorders -suppresses inflammation -reduces muscle fatigue, motor deficits and muscle degeneration -reduces lactic-acid buildup during heavy exercise -can improve muscular dystrophy -prevents metabolic syndrome -reduces fatty liver wth type 2 diabetes and obesity -prevents atherosclerosis -increases good cholesterol -help in weight loss -controls body fat and weight -directly protects the mitochondria -stimulates energy metabolism -treats diabetes -decreases bad cholesterol -normalizes glucose tolerance -improves insulin resistance -may treat metabolic acidosis -increases the pH of the blood -prevents cancer -an anti-tumor agent -suppresses tumor colony growth -inhibits blood vessel growth in human lung cancer cells -reduces side effects of cancer treatments -improves mortality and body weight loss caused by an anti-cancer drug, cisplatin -reduces kidney toxicity -prevents the loss of appetite on patients receiving radiation therapy -boosts skin health -improves wrinkles in the skin -reduces human skin cell damage from ultraviolet rays -enhances wound healing -limits damage of transplant organs -improves bladder dysfunctions -is cardio-protective -improves heart muscle function -protects the eye -if used as eyedrops, facilitates the recovery process after retinal injury -may prevent blindness caused by chemical burns of the eye -prevents hearing loss -protects auditory hair cells from oxidative damage -combats allergy -improves symptoms of atopic dermatitis -ameliorates kidney disease -reduces inflammation and blood pressure in hemodialysis patients -protects the liver -promotes gut health -protects the lungs -protects against radiation -relieves pain -prolongs life span -is antibacterial -promotes oral health So how can you convert your potable drinking water into Molecular Hydrogen Water? AIM Global introduces its newest product, ULTRA H2, an advanced Japanese Technology made in South Korea! It creates up to 1,500 parts per billion (PPB) of Molecular Hydrogen, the highest molecular hydrogen Generator! Just put Potable water inside and it will turn it into super-antioxidant water! And it costs much much lower than the machines being sold in the market today! When it comes to yours and your family's well-being, you should not aettle for anything less than the best, safest and most beneficial product! ULTRA H2 is going to change your life! It will become your most trustworthy ally in your efforts to stay beautiful and healthy! #AimGlobal #HealthyWater #ExtremeGlobalAchievers #HealthyDrink #HealthIsWealthc
Ultra H2 Molecular Hydrogen  Unboxing And Demo
 
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The ULTRA H2 MOLECULAR HYDROGEN The molecular hydrogen Ultra H2 creates up to 1,500 parts per billion molecular hydrogen that easily convert your drinking water into SUPER ANTIOXIDANT water! For more info click here: https://bit.ly/2JSJsco To order click here: https://bit.ly/2JSJsco How can molecular hydrogen from water benefit you and your family? Hydrogen water contains hydrogen molecules that act as powerful antioxidants. These molecules help neutralize the oxygen free radicals that cause disease, inflammation and aging. Due to its unique properties, molecular hydrogen has therapeutic benefits in virtually all organs of the body where it exerts antioxidant, anti-inflammatory, anti-obesity and anti-allergic actions without known side effects. Benefits of hydrogen water -An antioxidant and prevents brain damage -can protect cells and tissues from oxidative damage -prevents the development of Parkinson’s disease -reduces neurotoxic damage -Improve mood disorders -It can be used to improve depression and some mental disorders -press the inflammation -reduces muscle fatigue, motor deficits and muscle degeneration -reduces the accumulation of lactic acid during intense exercise -It can improve muscular dystrophy -prevents the metabolic syndrome -reduce fatty liver with type 2 diabetes and obesity -prevents atherosclerosis -increases good cholesterol -help in weight loss -controlles body fat and weight -Directly protects the mitochondria -stimulates the energy metabolism -trata diabetes -reduce bad cholesterol -normalizes glucose tolerance – Improves insulin resistance -Can treat metabolic acidosis -increases the pH of the blood -prevents cancer an antitumor agent – suppress the growth of tumor colonies -inhibits the growth of blood vessels in human lung cancer cells -reduce the side effects of cancer treatments – Improves mortality and body weight loss caused by an anti-cancer drug, cisplatin -reduce renal toxicity -prevents the loss of appetite in patients receiving radiotherapy -It works the health of the skin – Improves wrinkles in the skin -reduces the damage of human skin cells from ultraviolet rays Improves wound healing -limits the damage of the transplant organs – Improves bladder dysfunctions -is cardio-protective – Improves the function of the heart muscle -protects the eye -If used as eye drops, facilitates the recovery process after a retinal injury -Can prevent blindness caused by chemical burns of the eye -prevents hearing loss -protects auditory hair cells from oxidative damage – combat allergy – Improves the symptoms of atopic dermatitis -the kidney disease -reduce inflammation and blood pressure in patients on hemodialysis -protects the liver -promotes intestinal health -protects the lungs -protections against radiation -alleviate the pain – prolong the useful life -It is antibacterial -promotes oral health So how can you convert your drinking water into molecular hydrogen water? AIM Global presents its newest product, ULTRA H2, an advanced Japanese technology manufactured in South Korea! Create up to 1,500 parts per billion (PPB) of molecular hydrogen, the hydrogen generator with the highest molecular weight! Just put drinking water inside and turn it into super antioxidant water! And it costs much lower than the machines that are currently sold in the market! When it comes to the welfare of you and your family, you should not pay anything less than the best, safest and most beneficial product! ULTRA H2 is going to change your life! It will become your most trusted ally in your efforts to stay beautiful and healthy. Buy now: https://bit.ly/2JSJsco To order click here: https://bit.ly/2JSJsco
Views: 1480 Juvenal Sabado
Cancer: Cetuximab (Erbitux)
 
06:47
http://bowelcanceraustralia.org Mechanism of action for Cetuximab (Erbitux).
Views: 12745 Bowel Cancer Australia
Cancer Drugs - Learn with Visual Mnemonics!
 
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Website: http://VisualLearner.net/ Facebook: http://www.facebook.com/visuallearnerstudios Twitter: https://twitter.com/VL_Studios Alright...today, we will go over some common classes of drugs used in treating cancer and examples within each class. To remind you of this, this picture is a scene out of the latest sci-fi movie starring my main man...VIN EASEL. The plot?...Vin Easel and his crew battling a giant cancer crab. Vinca alkaloids: Vinblastine, Vincristine First up, are the Vinca alkaloids represented by Vin Easel. VIN BLASTING the crab is VINBLASTINE, and VIN with the CROSS is VINCRISTINE. Antimetabolites - Methotrexate, Fluorouracil, Mercaptopurine Next, we have the antimetabolites, represented by the T-Rex. The METH smoking T-REX is METH-O-TREX-ATE, his FLORAL shorts is FLUORO-URACIL, and his MERCEDES CAP is MER-CAP-TOPURINE. *we do not condone smoking meth* Taxanes: Paclitaxel Another class are the Taxanes, represented by the Tax Man. He’s is wearing a PACK of TAXES, which is PAC-LITAXEL. Alkylating Agents - Cyclophosphamide, Carboplatin, Cisplatin, Busulfan Lastly, we have the Alkylating agents, these are represented by the vehicles in the back line. The CYCLONE CYCLER on his PHOSPHATE bike is CYCLOPHOSPHAMIDE. The CAR of PLATINUM is CARBOPLATIN, and his SISter car is CIS-PLATIN. The BUS wielding FANS is BUS-UL-FAN. Alright folks, that’s it for this video! To learn more about visual mnemonics and Cancer drugs, including mechanisms of action and side effects, please check out our website at VisualLearner.net. Happy studying!
Views: 71150 VL Studios
Deborah Watkins Bruner on Side Effects From Platinum-Based Drugs in Ovarian Cancer
 
01:40
Deborah Watkins Bruner, PhD, RN, FAAN, professor, Nell Hodgson Woodruff School of Nursing, Emory University, discusses side effects associated with platinum-based drugs for the treatment of ovarian cancer. More from Oncology Nursing News: http://nursing.onclive.com/
Views: 62 OncLiveTV
Dr. Alan Sandler Discusses the Tivantinib Mechanism of Action
 
00:55
Alan Sandler, MD, division chief of Hematology and Medical Oncology at Oregon Health & Science University, discusses the mechanism of action for tivantinib (formally ARQ 197), an oral, small molecule, c-Met inhibitor currently being investigated in several trials, including MARQUEE, a phase III trial for patients with advanced, non-squamous, non-small cell lung cancer. To read more, visit http://www.onclive.com/onclive-tv/Dr-Sandler-Discusses-the-Tivantinib-Mechanism-of-Action
Views: 198 OncLiveTV
Lawrence Einhorn
 
44:49
This year marks the 40th anniversary of cisplatin’s approval by the FDA as an anti-cancer drug. Cisplatin (and the close analog, carboplatin) is known to be the “penicillin of cancer drugs,” because it has been one of the first, most widely prescribed, and most effective treatment for many cancer diagnoses. Cisplatin was approved by the FDA in 1978, revolutionizing the treatment of certain cancers, especially testicular, bladder, lung and stomach cancers, and saving countless lives.
Views: 11 Msu NatSci
Iressa, cancer information
 
02:21
Iressa, cancer information in English for Suddholm English voiceover: Swedish female top VO Nina Nu
Views: 281 Nina Nu Media AB
PD-L1 and TMB as biomarkers in the IMvigor211 trial of atezolizumab vs. chemo for bladder cancer
 
02:52
A highly anticipated topic at the 2018 Genitourinary Cancers Symposium, held in San Francisco, CA, was immune checkpoint inhibitor data for bladder cancer. Here, Thomas Powles, MD, of Barts Cancer Institute, London, UK, tells us about the Phase III IMvigor211 study (NCT02302807), which is investigating the use of atezolizumab vs. standard chemotherapy in bladder cancer patients who have relapsed following platinum-based chemotherapy. Prof. Powles highlights the PD-L1 biomarker detection used in this trial and the unexpected results from this, followed by the interesting further analysis, including that of tumor mutational burden (TMB).
Views: 120 VJOncology
Computational chemistry in the development of anti-cancer drugs - Jason Smith
 
36:39
A protein called indoleamine 2,3-dioxygenase (IDO) which occurs naturally in the human body has been found to be hijacked by cancer tumours and used to hide their presence from the body's immune system. In this lecture PhD student Jason Smith discusses his research on the use of a computational chemistry technique called virtual screening to identify anti-cancer drug candidates that inhibit IDO, and have the potential to slow tumour growth.
Views: 2565 Macquarie University
GRACEcast-079_Lung-Cancer_Challenging Cases in Lung Cancer: Unresectable Locally Advanced NSCLC
 
13:44
http://cancergrace.org/ Case-based discussion with multiple lung cancer experts on the controversial question of whether to recommend consolidation chemotherapy after concurrent chemotherapy and radiation for locally advanced NSCLC.
ULTRA H2 WATER Unboxing Video (Therapeutic Water)
 
01:00
The ULTRA H2 MOLECULAR HYDROGEN The Ultra H2 Molecular hydrogen creates up to 1,500 part per billion molecular hydrogen which readily turns your potable water into a SUPER ANTI-OXIDANT water! How can Molecular Hydrogen Water Benefit You and Your Family?? Hydrogen water contains hydrogen molecules that act as powerful antioxidants. These molecules help neutralize oxygen free radicals that causes diseases, inflammation and aging. Because of its unique properties, molecular hydrogen has therapeutic benefits in virtually every organ in the body where it exerts antioxidant, anti-inflammatory, anti-obesity, and anti-allergy actions with no known side effects. Hydrogen Water Benefits -an antioxidant and prevents brain damage -can protect cells and tissues from oxidative damage -prevents the development of Parkinson's disease -reduces neurotoxic damage -improve mood disorders -may be used for improving depression and some mental disorders -suppresses inflammation -reduces muscle fatigue, motor deficits and muscle degeneration -reduces lactic-acid buildup during heavy exercise -can improve muscular dystrophy -prevents metabolic syndrome -reduces fatty liver wth type 2 diabetes and obesity -prevents atherosclerosis -increases good cholesterol -help in weight loss -controls body fat and weight -directly protects the mitochondria -stimulates energy metabolism -treats diabetes -decreases bad cholesterol -normalizes glucose tolerance -improves insulin resistance -may treat metabolic acidosis -increases the pH of the blood -prevents cancer -an anti-tumor agent -suppresses tumor colony growth -inhibits blood vessel growth in human lung cancer cells -reduces side effects of cancer treatments -improves mortality and body weight loss caused by an anti-cancer drug, cisplatin -reduces kidney toxicity -prevents the loss of appetite on patients receiving radiation therapy -boosts skin health -improves wrinkles in the skin -reduces human skin cell damage from ultraviolet rays -enhances wound healing -limits damage of transplant organs -improves bladder dysfunctions -is cardio-protective -improves heart muscle function -protects the eye -if used as eyedrops, facilitates the recovery process after retinal injury -may prevent blindness caused by chemical burns of the eye -prevents hearing loss -protects auditory hair cells from oxidative damage -combats allergy -improves symptoms of atopic dermatitis -ameliorates kidney disease -reduces inflammation and blood pressure in hemodialysis patients -protects the liver -promotes gut health -protects the lungs -protects against radiation -relieves pain -prolongs life span -is antibacterial -promotes oral health So how can you convert your potable drinking water into Molecular Hydrogen Water? AIM Global introduces its newest product, ULTRA H2, an advanced Japanese Technology made in South Korea! It creates up to 1,500 parts per billion (PPB) of Molecular Hydrogen, the highest molecular hydrogen Generator! Just put Potable water inside and it will turn it into super-antioxidant water! And it costs much much lower than the machines being sold in the market today! When it comes to yours and your family's well-being, you should not aettle for anything less than the best, safest and most beneficial product! ULTRA H2 is going to change your life! It will become your most trustworthy ally in your efforts to stay beautiful and healthy!
Views: 4 Cherry DC
1st Chemo Treatment
 
05:15
So much waiting and test involved trying to get to the first chemo treatment. It was nerve racking and I went through... I don't know how many emotions. You can't tell from the video, but at times I was a wreck, but I got through the first one with thanks to many friends! Please subscribe to my channel and give my video that big thumbs up if you like it! JungleJayni Facebook: https://www.facebook.com/junglejayni/... Twitter: https://twitter.com/jaynisgotagun @Jaynisgotagun Instagram JayniMarie
Views: 2026627 Jayni Angeli
GRACEcast-059_Lung-Cancer_Expert Round Table - Ambiguous Imaging Results After Chemo/Radiation
 
15:41
http://cancergrace.org/ Case discussion with Drs. George Blumenschein of MD Anderson and Walter Curran of Emory University, covering management approaches for a stage IIIB locally advanced NSCLC with ambiguous imaging results after chemo and radiation were completed.
Erbitux For Colon Cancer
 
06:22
*** Please help me fight cancer now: donate to my cancer fund: *** http://www.MatthewDons.org
Views: 243 Kara Moon