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Support us on Patreon: https://www.patreon.com/speedpharmacology Follow us on Facebook: https://www.facebook.com/SpeedPharmacology/ Get Speed Pharmacology Merch Here: https://teespring.com/stores/speed-pharmacology **************************************************************************************************** Topics covered include: basic pathophysiology of hyperlipidemia, lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, vascular inflammation. Mechanism of action of antihyperlipidemic drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitor, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin, niacin, fenofibrate, gemfibrozil, colesevelam, colestipol, cholestyramine, ezetimibe, evolocumab, alirocumab, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), icosapent ethyl, fish oil.
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Text Comments (63)
Ranjith Jothi (5 days ago)
I always like ur videos sir.... We want more videos sir💓💓
Eull Light (19 days ago)
Y would someone dislike this!! Thanks alot
m.jawad Farooq (28 days ago)
thank you love from Pakistan
fastandeffective (1 month ago)
Lipid, cholesterol, statin, myths debunked by latest studies: www.bmj.com/content/361/bmj.k2243 bmjopen.bmj.com/content/6/6/e010401 www.ncbi.nlm.nih.gov/pubmed/28864332 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32252-3/fulltext http://www.dailymail.co.uk/health/article-5521767/Statins-hayfever-pills-fueling-antibiotic-resistance.html
mohammed aldaragi (1 month ago)
thanks to this amazing channel
zahraa zst (1 month ago)
Thank you so much
Adnan Shaikh (2 months ago)
Its getting harder,there are ads of about 19 minutes
Adnan Shaikh (2 months ago)
I just see full 3min advertisement for you bro, Please keep it up
Lee Ji Eun (2 months ago)
Thank you very much for the effort. This really helps. This is really simplified for my report.
غازي ت ت ت (2 months ago)
Thaaaaaaaaaaaaaaaaank yooooooooooooooooooou very muuuuuuuuuuuuuuch your mode of explain is very very very very fine
Today there is a deadly error in medicine. Patients with acute heart attacks and strokes, as well as physicians therapists do not know important information. Because of this error, several million people die each year. Therapists and cardiologists are 100% sure that they are treating atherosclerosis. But this is a mistake. In the vessels of the heart and brain with acute disruption of blood circulation - there is no atherosclerotic plaque. The cause of an acute stroke and an acute infarction is a completely different cholesteric plaque. Soft, elastic, appears quickly (in a few days). A soft cholesterol plaque can be treated before surgery. Cholesterol cylindrical plaque easily disappears, easily stretches. What is Arteriosclerosis? https://en.wikipedia.org/wiki/Arteriosclerosis « Arteriosclerosis is the thickening, hardening and loss of elasticity of the walls of arteries...The lesions of arteriosclerosis begin as the intima (innermost layer of blood vessel wall) of the arterial wall start to fill up with the deposition of cellular wastes. As these start to mature, they can take different forms of arteriosclerosis. All are linked through common features such as the stiffening of arterial vessels, thickening of arterial walls and degenerative nature of the disease» wikipedia. https://en.wikipedia.org/wiki/Atherosclerosis «Atherogenesis is the developmental process of atheromatous plaques. It is characterized by a remodeling of arteries leading to subendothelial accumulation of fatty substances called plaques. The buildup of an atheromatous plaque is a slow process, developed over a period of several years through a complex series of cellular events occurring within the arterial wall and in response to a variety of local vascular circulating factors». wikipedia. What is what really is in the arteries? On the giving video we can see cholesteric cylindrical plaque of yellow color, which is elastic, has cylindrical form, which follows the contour of vessel, has approximately the same thickness all around and has the hole in the middle and blood passes through it. This plaque kills, makes people with disabilities, increases the level of bad cholesterol in the blood. - https://www.youtube.com/watch?v=ImHe-7RoqVc&t=4s 1:49- 3:06 - https://www.youtube.com/watch?v=fGw0oBmmuHM 0:27 , 2:06-2:15 - https://www.youtube.com/watch?v=CE2UMvOvWnU 2:04- 2:35 -https://www.youtube.com/watch?v=wQ1yIT8dt3Y-- --25:13- 25:46 cholesteric plaque - - https://www.youtube.com/watch?v=R8dVYf-LV44&feature=youtu.be 4:58, 13:51 - https://www.youtube.com/watch?v=yqx_19N6eWA&feature=youtu.be 1:52 -2:15 - https://www.youtube.com/watch?v=arZiYgt200M&feature=youtu.be 17:58- 20:23 - https://www.youtube.com/watch?v=5n3npP1a58E&feature=youtu.be 58:15, 59:22,1:11:44 - https://www.youtube.com/watch?v=Oa8XV27KNAY&feature=youtu.be, 00:54, 11:05 - https://www.youtube.com/watch?v=wYpyj97Jmxg&feature=youtu.be 0:47 - https://www.youtube.com/watch?v=tSdF6_1DGls&t=258s 4:10-4:20 - https://www.youtube.com/watch?v=hRBFnNl-SpU 1:09-3:19 Medical Hypotheses 106 (2017) 61–70 https://doi.org/10.1016/j.mehy.2017.07.001 In this article is given the new insight about the affection of stress on the increase of level of low density lipoproteins (LDL) in the blood, which is connected with the disturbance of hydrodynamics in the bloodstream, the attention was paid to the cylindrical cholesterol plaque, and it’s classification. The disturbance of hydrodynamics of blood under the stress leads to the formation of a cylindrical cholesterol plaque, which repeats the contour of the vessel, and leads to the ischemic disorders of the heart and brain. The cylindrical cholesterol plaque goes through several stages of development: friable, yielding, dense, old. In the case of destruction of friable, fresh cholesterol plaque, releases a big quantity of lowdensity lipoproteins. This leads to the pathological increase of level of LDL in the blood. In the case of long disturbance of hydrodynamics, occurs the formation of strong links between low-density lipoproteins. Yielding cholesterol plaque is formed. Further maturation of cylindrical cholesterol plaque, leads to it’s densifying and damage. We may emphasize, that short periods of strong contraction and expansion of vessels lead to the increase of level of LDL in the blood. Self-dependent restoration of normal level of LDL in blood occurs in the case of restoration of pressure in the limits of numbers, which are specific for particular person, and which don’t exceed the physiological standard. Among patients with long duration of stress, the duration of vasospasm increases. LDL, without having a possibility to crumble, begin to stick together and form the yielding cylindrical plaque. It is characterized by having of not so strong connection with the vascular wall, and maintains only at the expanse of iteration of the vascular wall, it has cylindrical shape, is elastic and yellow. The thickness and length of walls depends on the degree of cross-clamping during the time of formation of yielding cylindrical plaque. In the case of stopping of spasm, yielding cylindrical plaque can resolve slowly. Among hypotensive and individuals, which have normal pressure, the increase of level of LDL isn’t noted. There aren’t such investigations, where such link was noted. The increasing of level of LDL among these people (especially under the stress) can say about cases of short-term increase of pressure, which could be unnoticed. These patients require pressure monitoring and, accordingly, the adjustment of the state of stress and anger. Youtube: Atherosclerosis? No!!! Cylindrical cholesterol plaque!!! Pathophysiology https://www.youtube.com/watch?v=MIfAVTDvM2o The proposed hypothesis more fully reflects the mechanism of abnormal increase of level of LDL in the blood. Were disclosed cause-effect relations between stress, short-term increase of pressure and an increase of level of LDL in the blood; between stress and ischemic disorders in heart and brain. Was described the mechanism of formation and stages of development of cylindrical plaque (CP). Was given an explanation for the reasons of increasing of the level of LDL among hypertensives, who are on the strict diet without cholesterol. Was explained the absence of increasing of the level of LDL among hypotensives, who take large amount of food with cholesterol. Natural restoration of level of LDL in the limits of PS can only be achieved under certain conditions: the full restoration of the work of the central nervous system and autonomic nervous system, the reduction and complete ceasing of stress and restoration of pressure, which mustn’t be above the physiological standard.
nagarjun Gagrai (2 months ago)
Is the action of phytosterol in lowering LDL is the same in the mechanism of action of Ezetimibe?
+Speed Pharmacology Thank you so much. This is a big help. You're such a great person. 👍
Speed Pharmacology (3 months ago)
Muhammad Bilal (3 months ago)
Thanku Sir... Sir Plz make a video on CHF and Asthma...
naveed ali (3 months ago)
Rahul Swami (4 months ago)
What is flashing caused by niacin?
Garima Singh (4 months ago)
Thnku so much
aida al-oatti (4 months ago)
thank you sir!
Dev Kumar (5 months ago)
Great job sir very nice👍👍👍
Taha Nayyar (5 months ago)
If i pass tomorrow i am gona name my kids after your channel
Adnan Shaikh (2 months ago)
Taha Nayyar lol, So...do you passed?😜
Mawadda shaban (7 months ago)
That is amazing !
Supriya M (7 months ago)
Can u please make a video on Cardiac glycosides.
Zipho Madolwana (8 months ago)
The best
bshayerahmad (8 months ago)
thank you so much this is very helpful
Temi Wright (8 months ago)
Zade Batarseh (8 months ago)
Thank you! 2hr lecture in class summed up 1000x better in less than 15 min!
Anjali Kumari (8 months ago)
This is so amazing so handy in short perfect to the point explanations. The effort is fully appreciated, Sir. Thanks.
Krishna Hanchate (8 months ago)
Please a video on pharmacology of asthma🙏🙏 or reply a link having a good video on it
hawraa mahdi (8 months ago)
Thank youuuuu soo much ..🙆 just another amazing work .. Keep hard working ...you r simply great 😢😌👏💛
M. Ameer (9 months ago)
This video is awesome! now I love pharmacology beacuse of you! thanks
Bitkigibi Yetistirdi (9 months ago)
Bitkigibi Yetistirdi (9 months ago)
Fatemah Eldeeb (9 months ago)
Excellent video! Please keep them coming.
Karim & Marianne Mikhail (9 months ago)
Sachin (10 months ago)
surumi bp (10 months ago)
thank u so much sir....plz post antibiotic and anticancer drugs video sir
Rahul Tiwari (11 months ago)
Great lecture sir... Plz keep posting new topics. Thanks alott sir
Shelly Lynn (11 months ago)
Your videos are so clear, straight forward, and thorough! Thank you! Please make more!
João César (11 months ago)
Love you man S2
Sara 90 (11 months ago)
thank u this video was amazing
Nousheen Arshad (11 months ago)
very very excellent
Muhammad Usman (11 months ago)
sir your videos are amazing and easy to understand wounder-full. sir when you are providing lecture on ANTI HISTAMINES,,???
Sapana Yonghang (11 months ago)
Your every videos are amazing! I have gone through each of them! You should make more of these! :)
Sanjana Jadhav (1 year ago)
can u upload videos of chemotherapy drugs ?
Reu P (1 year ago)
Thank you so much!
Said Gitta (1 year ago)
Superb pharmacology lectures.Thanks a million
mhmd fadoul (1 year ago)
thanks for this interesting lesson. would you talk about contraceptives
medi medico (1 year ago)
please do more videos regarding pharmacology
Seema Firdous (1 year ago)
you are amazing!!!
Sharif Khan (1 year ago)
thank u for help that video
Ginu John (1 year ago)
sir can u make a video on drugs affecting blood please
Ada Ndriollari (1 year ago)
Thane you very much from italy !!!
Shahran Sabah (1 year ago)
Thanks a lot but could you make video about anticancers
rian x (1 year ago)
I'm studying dentistry and this is extremely helpful for learning patients' medications which aren't taught well in school. I really appreciate your work, please keep up the great job.
Heba Abd El Samie (1 year ago)
can you make video on drug for epilepsy and NSAID Iam waiting for you so amazing video but please hurry soon I will have exam and I really appreciate your help
AHMED N (1 year ago)
good explanation. thanks
Mina dz (1 year ago)
this came just in time. . i have a pharmacology exam tomorrow and this video saved me so much time. . thanks a lot!
Nouf Alf (1 year ago)
Ohhh man I wish you put this up. A week ago 😭💔
ninou norino (1 year ago)
thank you very much
DR mubasher (1 year ago)
👍🏻👍🏻✌🏻very fantastic
Nicholas Lem (1 year ago)
Thank you so much...You are amazing...I really love your videos...You really make things easier to understand....Thanks to you i got an A this semester...Thanks man

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