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Oxygen free radicals & cellular injury - causes, symptoms & pathology

2086 ratings | 136515 views
What are free radicals? Well, in the body, free radicals typically take the form of reactive oxygen species, which include peroxides, superoxide, and the hydroxyl radical. Find more videos at http://osms.it/more. Study better with Osmosis Prime. Retain more of what you’re learning, gain a deeper understanding of key concepts, and feel more prepared for your courses and exams. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways and more when you follow us on social: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Osmosis's Vision: Empowering the world’s caregivers with the best learning experience possible.
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Text Comments (108)
Tayyiba Mubasher (19 days ago)
Ed Sanchez (1 month ago)
he misspelled acetaminophen
Brittany Bettingen (1 month ago)
perfect thank you
Lilek Fialový (1 month ago)
I hope there is anyone who will answer me. I just didn't get why is it pointed with bullet mark and not just anion of an element, if atom or molecule gets one e- it becomes anion so why is this called radical. Please don't be mad with me if I'm wrong but I have been so confused so please help me find a difference.
Luke Chavez (1 month ago)
Very thorough, thank you!
AcuSalud Truquitos (3 months ago)
Great video! which animation software did you use to create this video? thanks!
Rene Lazzaro (3 months ago)
Very similar video to the one on Pathoma, but this is better
ganesh kolapkar (3 months ago)
very nice lecture we need more it will make biochem very easy
camofrog (3 months ago)
This is by far the best video on this subject that I can find. Everything else is either pseudoscience or sloppy amateur ramblings. Thank you so much for this.
Steve Phillips (3 months ago)
Amazing video brilliant coverage clear and easy to follow; have subscribed.
hawzhir taha (3 months ago)
Great !
Disabler (4 months ago)
People love free stuff thats why its so hard to convince people that these are bad..
MisterTutor2010 (4 months ago)
This video was TOTALLY RADICAL :)
MisterTutor2010 (4 months ago)
Superoxide's weakness in Kryton :)
Ernell Saunders (5 months ago)
I don't know you.. but I freakin love you dude!!
Esty B (5 months ago)
How do you get rid of trichloromethyl radical to prevent fatty liver? Is it reversible?
Qubais Alobeidi (6 months ago)
seriously i have no words ,to tell you how thankful i am )))))))amazingggggggg
Sedra Ahmad (6 months ago)
Cristiano Messi (6 months ago)
Great video..but I think, Catalase and Glutathione peroxidase both act in Hydrogen peroxide. I don't know any enzymes that can neutralize Hyroxyl radical specifically.
Guitar Girl (6 months ago)
A very helpful video...thanks a lot!!
Amy Shepherd (8 months ago)
Really well-explained thanks! :D Just a heads up, I found out that only vitamins E and C are antioxidants not vitamin A :)
Shupom Rayhan (8 months ago)
Why would O2 become H2O2 or Hydroxyl if electrons are added? Shouldn't that be proton since Proton = H+?
Sakshi Hadap (8 months ago)
Plz do a video on inflammation
Andrea Rose (10 months ago)
Thanks!! Keep up the good work!
Osmosis (10 months ago)
That's the plan! Thanks for the kind words, Andrea! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on YouTube? Check it out here:   http://bit.ly/2u35D6J
leonardo silva nobrega (10 months ago)
What program did you use to do that lesson? By the way, you made a perfect lesson using it, thank you so much!!
leonardo silva nobrega (10 months ago)
Thank youuu very much =)
Osmosis (10 months ago)
We have a video on that! Check it out! https://www.youtube.com/watch?v=rALOCwzv4zQ
Alaa a (11 months ago)
A reference video for free radical cell injury, thank you <3
Osmosis (10 months ago)
Glad we could help, Alaa! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on YouTube? Check it out here:   http://bit.ly/2u35D6J
sonia maria (11 months ago)
What will happened if Anti Oxidant give electrons to O2, does O2 converted to superoxide???
Kay Vee (11 months ago)
Osmosis (11 months ago)
Thanks, Kay Vee!
no8a elanee8a (11 months ago)
Great one 😻👌🏼
Osmosis (11 months ago)
Thanks, no8a elanee8a! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on YouTube? Check it out here:   http://bit.ly/2u35D6J
ze sam (1 year ago)
I can't thank enough for all the vids u upload
Osmosis (1 year ago)
Thanks a lot, Ze Sam! Did you know that if you like & review us on Facebook then you’ll get access to our videos hours or even days before they’re published on YouTube? Check it out here:  https://www.facebook.com/pg/OsmoseIt/reviews
sara jade (1 year ago)
great vid
rajib sarker (1 year ago)
Khamis Zananiri (1 year ago)
the best that i have ever seen on the same topic. simple and super cool. thank you
Khamis Zananiri (1 year ago)
Vinay Rajbhar (1 year ago)
Hey guys can you plz make the video on pathology of different lobes in brain, my exams are going on and your video it's really helpful thanks
Osmosis (1 year ago)
We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis
Wesley Richardson (1 year ago)
When he says electrons which are donated to the oxygen does he mean hydrogen ions?
Mark Ovich (8 months ago)
he would technically mean, hyrdogen atom, one proton, one electron. a hydrogen ion would just be a proton, and no electron. For oxidative phosphorylation, a hydrogen ion comes from outside the mitochondrial matrix and the electron is donated, which pulls the hydrogen ion through the cell wall, to make H2O. please correct if wrong. Thanks
Azy Chua (1 year ago)
Interested to know this as well... any expert may share the knowledge?
Wesley Richardson (1 year ago)
I dont get it can someone please help? If oxygen gains an electron how does it gain a hydrogen such as in super oxide ion to hydrogen peroxide?
Mark Ovich (11 months ago)
the hydrogen ion is positive, the oxygen gets reduced (gains electron, makes the oxygen more negative) positive and negative attractive forces are at play. and hydrogen follows the rules and bonds to complete rule chemistry.
Anna Maria (1 year ago)
I'm a huge fan of Osmosis! Thank you for all of your videos!
Anna Maria (1 year ago)
Just did. Keep it up! :)
sobia anum (1 year ago)
Kimberly Felker (1 year ago)
I agree I believe the glutathione peroxidase acts on Hydrogen Peroxide...2 Glutathione (Reduced)+ H2O2 ->Glutathione Peroxidase= Glutathione (Oxidized) + 2 H2O
Marius Pheiffer (1 year ago)
Great video!
ZUBAIR ZUBI (1 year ago)
Very helpful video thank you so muxh sir keep it up ! :)
PrettyGirlPractice (1 year ago)
You are a lifesaver!!! Using this video to study for Med School and you are spot on! :)
Naglaa F Abuzaid (1 year ago)
Very helpful. Thank you. (but i think glutathione peroxidase acts on the peroxide)
Naglaa F Abuzaid (1 year ago)
Osmosis. You could find this in many papers and textbooks. For instance, Lippincott 6th ed. (p. 520), Marks' 4th ed. (p. 448) and Harpers (2012, p.225). I hope it helps and thank you for your great work.
Osmosis (1 year ago)
Could you share with us a credible source that indicates this?
-.- Cat (1 year ago)
My major is nowhere near a medical one, but I love watching these videos!! Probably because they enable me to fool others into thinking I actually know what I'm talking about :)
Guy Benkovich (1 year ago)
hey guys just wanted to inform you about something you got wrong the glutathione peroxidase dose act on H2O2 not on the hydroxyl redical other than that great video!
Federico Egli (3 months ago)
This is absolutely true. Nice catch
Steve Phillips (3 months ago)
"the hydroxyl radical cannot be eliminated by an enzymatic reaction," that sounds  rather deep for me as I'm new here, but thought he said more less the opposite.
Grace Liu (1 year ago)
Thanks, I think so too. And H2O2 adds 2 electrons to become H2O.
carlos gonzalez (1 year ago)
came here specifically for that part too, thanks
Clint Dalton (1 year ago)
Thanks for posting this. I came here specifically to ask about that, since I read elsewhere that “unlike superoxide, which can be detoxified by superoxide dismutase, the hydroxyl radical cannot be eliminated by an enzymatic reaction.”
LU MF (1 year ago)
Thank you my friend.You are the best
Talkative Ape (1 year ago)
I find this very interesting because I have just started vaping and vaping can create free radicals that can create cancer!!! o_O Why is no one in the vaping community talking about this?
Jovan Kuzmanovski (1 year ago)
A great, great video! Thank you very much, greetings from Macedonia!
thank you for explaining but you can speak more slowly to understand informations well.. any way.. thank you ☺
K Star (1 year ago)
Hello - a wonderful video, thank you. I have a question - you mention that glutathione peroxidase works on the hydroxyl radical. This seems to be different to what it says in at least some other textbooks. Is this a new discovery? Are you able to shine any light on this difference of opinion? Thank you.
John McNulty Jr. (1 year ago)
Fantastic. Thank you!
Shakarhaba (1 year ago)
Would you be so kind of telling me the program you use to draw? I do speeches and seminars and would be lovely to have this tool. Your videos are really interesting and intuitive! kudos
Osmosis (1 year ago)
We use Camtasia and Sketchbook
sushrut kulkarni (1 year ago)
thanku nice video
Evans Ojwak (1 year ago)
Wow, my background in chemistry and bio is zero but your explanation is amazingly, wonderful
aquamarinefire11 (1 year ago)
Your videos are amazing, i'm currently studying pathophysiology and I find these so helpful. Thank you so much!
Victoria Gaona (1 year ago)
I'm so happy that I found this channel at the beginning of my pathology course :D
ALI AlTrabolsi (1 year ago)
This is the same way Dr.Sattar explained this. Good job👍👏
Vina Latif (1 year ago)
Koen Manusama (1 year ago)
A really good explanatory video! Props!
Osmosis (1 year ago)
Thanks Koen.
vvdv (2 years ago)
I dont get the part about the chain reaction and lipid peroxidation. If an electron is stolen shouldnt that atom become stable? Why does it cause a change reaction of damage?
Jonathan Frank (1 year ago)
In normal conditions, Vitamin E,A,C deals with that because they can donate e- , but in pathological conditions where like in ischemia, the cells are devoid of nutrients and O2, which when prolonged depending on the type of tissue cells will lead to irreversible injury .
vvdv (1 year ago)
+Ge-vivin Vinister How does it ever stop?
Ge-vivin Vinister (1 year ago)
vvdv yes, the atom becomes unstable and hence to achieve stability once again it borrows electrons from the next atom on the lipid cell membrane. Which sets off a chain reaction.
Yank the roots (2 years ago)
These videos are gold!
Osmosis (1 year ago)
J. Gupta (2 years ago)
amazingly done, big thanks! hopefully your channel will get bigger!!
Osmosis (2 years ago)
Muniba Safdar (2 years ago)
bundle of thanks
Osmosis (2 years ago)
gadiscymraes (2 years ago)
amazing! Finally all about ROS explained in one place and easy to understand! I wish I'd found your site in 1st year!! Subscribed!!
Osmosis (2 years ago)
+gadiscymraes Thanks so much!
dipankar acharjee (2 years ago)
thank you so much sir for this vedio,,
Osmosis (2 years ago)
+dipankar acharjee You're welcome. =)
Louis L (2 years ago)
Good sharing. Thanks. May I know what software that you use to make this presentation? Thanks again.
Osmosis (2 years ago)
+Fah Ah Yes - we use Sketchbook Pro and Camtasia.
As Insane As possible (2 years ago)
I'm just waiting for when you have covered every illness xd
Osmosis (2 years ago)
+Fire Razor Eventually.... we hope!
As Insane As possible (2 years ago)
#MeetTheGuyWho'sGonnaEndUpSavingUsFromEbola aka Osmosis! i meant bird flue DAMN IT!
Rory Tinker (2 years ago)
Cheers for making this viedo's public :)
Osmosis (2 years ago)
+Rory Tinker Thanks!
Ramos Siahaan (2 years ago)
very good video, thankyou verymuch for this information
Osmosis (2 years ago)
+Ramos Siahaan No problem Ramos! You're very welcome.
William L (2 years ago)
Should have more views
Osmosis (2 years ago)
+William L Thanks William. Spread the word to your friends!
Too Sweet (2 years ago)
nice video again ! thumbs up :)
Osmosis (2 years ago)
+PUnk RAbz Thanks for the support. Please spread the word to your friends. =)

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