The role of nitric oxide in erectile dysfunction: implications for medical therapy.
Erectile dysfunction is a common, multifactorial disorder that is associated with aging and a range of organic and psychogenic conditions, including hypertension, hypercholesterolemia, diabetes mellitus, cardiovascular disease, and depression. Penile erection is a complex process involving psychogenic and hormonal input, and a neurovascular nonadrenergic, noncholinergic mechanism. Nitric oxide (NO) is believed to be the main vasoactive nonadrenergic, noncholinergic neurotransmitter and chemical mediator of penile erection. Released by nerve and endothelial cells in the corpora cavernosa of the penis, NO activates soluble guanylyl cyclase, which increases 3',5'-cyclic guanosine monophosphate (cGMP) levels. Acting as a second messenger molecule, cGMP regulates the activity of calcium channels as well as intracellular contractile proteins that affect the relaxation of corpus cavernosum smooth muscle. Impaired NO bioactivity is a major pathogenic mechanism of erectile dysfunction. Treatment of erectile dysfunction often requires combinations of psychogenic and medical therapies, many of which have been only moderately successful in the past. The advent of oral phosphodiesterase type 5 (PDE-5) inhibitors, however, has greatly enhanced erectile dysfunction treatment; patients have demonstrated high tolerability and success rates for improved erectile function. The efficacy of the PDE-5 inhibitors also serves to illustrate the importance of the NO-cGMP pathway in erectile function since these agents counteract the degradation of NO-generated cGMP. Because not all patients respond to PDE-5 inhibitors, additional therapies are being investigated, such as soluble guanylyl cyclase activators and NO donors, which act on NO-independent and NO-dependent pathways, respectively.
thing circulation is a big factor start walking watch your simple carbs intake ! loose weight then watch bigger then ever just walk after breakfast walk after lunch walk after dinner ad in 4 months time see your skinnier and harder !
ED. another great business! as the supply of foods are poisons and degenerated there will be an increase in Erectile Dysfunction, Heart Problems Cancer ect. :) Nothing like making money Killing Peoples! MD. more dollars.
Testosterone also decreases with age also. The arterial walls may be a greater cause of ED but how can you say it's the only age related ED issue when low T can also be involved and Testosterone does decrees as we age.
If you watch porn and can't get it; you're done...PERIOD! Hope I never get there but I'm over the hill now and was interested. Which landed me here. My advice; eat plenty of watermelon. My wife tells me I'm INSANE because I always want to just jump her....lol
I'm curious of using nitric oxide as it could trigger pumping more blood into the brain, which could result in severe headache etc. Once, I had nitric oxide skin patches, which I had to stop for migraine-like headache.